Ovatoxin-a

Putative palytoxin and ovatoxins were detected, being ovatoxin-a the dominant component. The highest concentration per cell almost coincided with maximum Ostreopsis abundances. Novel Aspect: The improved UHPLC-HRMS method evidences the presence of putative palytoxin and ovatoxins in the Ostreopsis bloom in a NW Mediterranean beach.

Structure elucidation of ostreocin-A and ostreocin-E1, novel palytoxin analogs produced by the dinoflagellate Ostreopsis siamensis, using LC/Q-TOF MS. Bioscience, Biotechnology, and Biochemistry: Vol. 83, No. 3, pp. 381-390. We've detected an unusually high number of searches coming from your location. Are you a real person, or a robot?

14.07.2021 Ovatoxin-a

View This Abstract Online; Effects of copper and butyltin compounds on the growth, photosynthetic activity and toxin production of two HAB dinoflagellates: The planktonic Alexandrium catenella and the benthic Ostreopsis cf. ovata. Laura Pezzolesi, Università di Bologna, Scienze Biologiche, Geologiche e Ambientali Department, Post-Doc. Studies Harmful algal blooms, Benthic Harmful Algal Bloom, and Phytoplankton ecology and distribution. Jun 25, 2020 · Pelin M, Forino M, Brovedani V, Tartaglione L, Dell'Aversano C, Pistocchi R, Poli M, Sosa S, Florio C, Ciminiello P, Tubaro A. Ovatoxin-a, a palytoxin analogue isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic activity and ELISA detection. Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak P Ciminiello, C Dell’Aversano, E Fattorusso, M Forino, L Tartaglione, 42-hydroxypalytoxin, ostreocin-d, ovatoxin-a, -b,-c,-d, -e and -f and mascarenotoxin-a, -b and -c.

Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve molluscs (mussels) and herbivorous echinoderms (sea urchins). The total content accumulated in urchins reached 450 µg PLTX eq/kg total flesh (summer 2008).

In 2005 and 2006 blooms of these algae occurred in the Mediterranean sea. All those affected needed hospitalization.

26 Jul 2016 The most abundant palytoxin analogues in Mediterranean strains, Ovatoxin-a ( OVTX-a) and its analogues, can accumulate in several marine

Studies Harmful algal blooms, Benthic Harmful Algal Bloom, and Phytoplankton ecology and distribution. Jun 25, 2020 · Pelin M, Forino M, Brovedani V, Tartaglione L, Dell'Aversano C, Pistocchi R, Poli M, Sosa S, Florio C, Ciminiello P, Tubaro A. Ovatoxin-a, a palytoxin analogue isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic activity and ELISA detection.

The total content accumulated in urchins reached 450 µg PLTX eq/kg total flesh (summer 2008). Availability of pure ovatoxin-a will open the double prospect of fully evaluating its toxicity and preparing reference standards to be employed in LC/MS quantitative analyses.

Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three Palytoxin is a highly toxic non-proteinaceous marine natural product that can pass through the food chain and result in human illnesses. A recent review by the European Food Safety Authority concluded that palytoxin requires regulation in seafood and a limit of 30 μg kg⁻¹ for shellfish flesh was sug … Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak Sommaire In this article we report on the liquid chromatography tandem mass spectrometry (LC-MS) investigation of plankton samples collected in the summer of 2006 along the Ligurian coasts, coinciding with a massive bloom of the tropical microalga LC–MS analysis suggests that ovatoxin-a AC is dideoxy-42-hydroxy-44-deoxy-palytoxin. The unidentified deoxy-positions can be assigned both between C16 and C20 and between C53 and C73. Toxin profiles of Ostreopsis collected in the middle to southern coastal area in Japan were similar irrespective of clades classified by the phylogenetic analysis reported in our previous study. Currently, the benthic dinoflagellate Ostreopsis cf.

17/2/2012 Ovatoxin-a and palytoxin accumulation in seafood in relation to Ostreopsis cf. ovata blooms on the French Mediterranean coast Mar Drugs. 2012 Feb;10(2):477-96. doi: 10.3390/md10020477. Epub 2012 Feb 17. Authors Zouher 1/1/2008 Abstract.

Laura Pezzolesi, Università di Bologna, Scienze Biologiche, Geologiche e Ambientali Department, Post-Doc. Studies Harmful algal blooms, Benthic Harmful Algal Bloom, and Phytoplankton ecology and distribution. Jun 25, 2020 · Pelin M, Forino M, Brovedani V, Tartaglione L, Dell'Aversano C, Pistocchi R, Poli M, Sosa S, Florio C, Ciminiello P, Tubaro A. Ovatoxin-a, a palytoxin analogue isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic activity and ELISA detection. Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak P Ciminiello, C Dell’Aversano, E Fattorusso, M Forino, L Tartaglione, 42-hydroxypalytoxin, ostreocin-d, ovatoxin-a, -b,-c,-d, -e and -f and mascarenotoxin-a, -b and -c. However only the chemical structures of PLTX, ostreocin-d, ovatoxin-a and 42-hydroxypalytoxin have been characterized [4-11].

ovata in the Mediterranean Sea. Ovatoxin A has two oxygen atoms less than PlTX but it is not known from which part of the molecule the oxygen atoms are missing (Ciminiello et al. 2006 (Ciminiello et al. , 2008 Guerrini et al An Italian Ostreopsis strain (KAC 85) was also analyzed by LC–MS as a reference material of Ostreopsis and the presence of ovatoxin-a, -b, -c, -d, and -e was re-confirmed. The most dominant palytoxin analogue in Japanese Ostreopsis was a novel palytoxin analogue, which was identified as an isomer of ovatoxin-a. Dinoflagellates of the genus Ostreopsis are known to cause (often fatal) food poisoning in tropical coastal areas following the accumulation of palytoxin (PLTX) and/or its analogues (PLTX group) in Fragmentation pattern of palytoxin was used as template to gain detailed structural information on ovatoxin-a, the main toxin produced by Ostreopsis ovata, (observe correct font) a benthic dinoflagellate that currently represents the major harmful algal bloom threat in the Mediterranean area. Oxidation of palytoxins, ovatoxins or ostreocins using periodic acid generates two nitrogen-containing aldehyde fragments; an amino aldehyde common to these toxins, and an amide aldehyde that may vary depending on toxin type. The U.S. Army Medical Research Acquisition Activity (USAMRAA) is conducting market research to obtain information regarding services provide Isolation and purification of ovatoxin-a from O. ovata cell pellets to the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

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A formerly unknown derivative of palytoxin, ovatoxin-a, produced as a marine aerosol by the tropical dinoflagellate Ostreopsis ovata caused hundreds of people in Genoa, Italy, to fall ill. In 2005 and 2006 blooms of these algae occurred in the Mediterranean sea. All those affected needed hospitalization.

Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak P Ciminiello, C Dell’Aversano, E Fattorusso, M Forino, L Tartaglione, 42-hydroxypalytoxin, ostreocin-d, ovatoxin-a, -b,-c,-d, -e and -f and mascarenotoxin-a, -b and -c. However only the chemical structures of PLTX, ostreocin-d, ovatoxin-a and 42-hydroxypalytoxin have been characterized [4-11].